JUN Antibody

Product Specifications

Background

JUN interacts directly with specific target DNA sequences to regulate gene expression. Jun recognizes the AP-1 consensus sequence TGACTCA, a response element that confers sensitivity to one of the tumor-promoting Phorbol esters, 12-O-tetradecanoyl-phorbol-13-acetate (see also: TRE, TPA response element) . Jun itself forms homodimers or heterodimers with junD and junB and also interacts with the oncogene product fos, forming jun-fos heterodimers.

NCBI Gene ID

3725

Swiss Prot

P05412

Accession Number

P05412

Host

Rabbit

Reactivity

Human

Immunogen

This JUN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 41-70 amino acids from human JUN.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Immunology, Signal Transduction, Inflammasomes

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

36 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

JUN

NCBI Official Name

Transcription factor AP-1

NCBI Organism

Homo sapiens

Background Reference 01

Fujita, S., J. Mol. Biol. 378 (3), 492-504 (2008)

Background Reference 02

Gan, X.Q., Cell Biol. 180 (6), 1087-1100 (2008)

Background Reference 03

Yogev, O., Cancer Res. 68 (5), 1398-1406 (2008)

Other Product Names

Transcription factor AP-1, Activator protein 1, AP1, Proto-oncogene c-Jun, V-jun avian sarcoma virus 17 oncogene homolog, p39, JUN

Tested Applications

Protein ID

135298

Physical Properties

Liquid

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