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CB1 Antibody

Product Specifications

Background

This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene. [provided by RefSeq].

NCBI Gene ID

1268

Swiss Prot

P21554

Accession Number

P21554

Host

Rabbit

Reactivity

Human

Immunogen

This CB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 161-187 amino acids from the Central region of human CB1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Obesity, Neuroscience, Signal Transduction, Growth Factors

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

53 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

CNR1

NCBI Official Name

Cannabinoid receptor 1

NCBI Organism

Homo sapiens

Background Reference 01

Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)

Background Reference 02

Van Laere, K., et al. J. Nucl. Med. 51 (9) :1413-1417 (2010)

Background Reference 03

Larrinaga, G., et al. Histol. Histopathol. 25 (9) :1133-1138 (2010)

Background Reference 04

Monteleone, P., et al.Clin Psychopharmacol 30 (4) :441-445 (2010)

Other Product Names

Cannabinoid receptor 1, CB-R, CB1, CANN6, CNR1, CNR

Tested Applications

WB

Protein ID

115562

Physical Properties

Liquid

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