TFEC Antibody

Product Specifications

Background

Transcriptional regulator that acts as a repressor or an activator. Acts as a transcriptional repressor on minimal promoter containing element F (that includes an E-box sequence) . Binds to element F in an E-box sequence-specific manner. Acts as a transcriptional transactivator on the proximal promoter region of the tartrate-resistant acid phosphatase (TRAP) E-box containing promoter (By similarity) . Collaborates with MITF in target gene activation (By similarity) . Acts as a transcriptional repressor on minimal promoter containing mu E3 enhancer sequence (By similarity) . Binds to mu E3 DNA sequence of the immunoglobulin heavy-chain gene enhancer (By similarity) . Binds DNA in a homo-or heterodimeric form.

NCBI Gene ID

22797

Swiss Prot

O14948

Accession Number

O14948

Host

Rabbit

Reactivity

Human

Immunogen

This TFEC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 179-205 amino acids from the Central region of human TFEC.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Chicken, Mouse, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

39 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

TFEC

NCBI Official Name

Transcription factor EC

NCBI Organism

Homo sapiens

Background Reference 01

Mansky, K.C., et al. J. Leukoc. Biol. 71 (2) :304-310 (2002)

Background Reference 02

Chung, M.C., et al. Biochemistry 40 (30) :8887-8897 (2001)

Background Reference 03

Steingrimsson, E., et al. Development 125 (23) :4607-4616 (1998)

Background Reference 04

Yasumoto, K., et al. Biochim. Biophys. Acta 1353 (1) :23-31 (1997)

Other Product Names

Transcription factor EC, TFE-C, Class E basic helix-loop-helix protein 34, bHLHe34, Transcription factor EC-like, hTFEC-L, TFEC, BHLHE34, TCFEC, TFECL