CTNS Antibody
Product Specifications
Background
This gene encodes a seven-transmembrane domain protein that functions to transport cystine out of lysosomes. Its activity is driven by the H+ electrochemical gradient of the lysosomal membrane. Mutations in this gene cause cystinosis, a lysosomal storage disorder. Alternative splicing results in multiple transcript variants.
NCBI Gene ID
1497
Swiss Prot
O60931
Accession Number
O60931
Host
Rabbit
Reactivity
Human
Immunogen
This CTNS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 341-367 amino acids from the C-terminal region of human CTNS.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
42 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
CTNS
NCBI Official Name
Cystinosin
NCBI Organism
Homo sapiens
Background Reference 01
Taranta, A., et al. Pediatr. Nephrol. 25 (7) :1263-1267 (2010)
Background Reference 02
Bellomo, F., et al. Free Radic. Biol. Med. 48 (7) :865-872 (2010)
Background Reference 03
Kumar, A., et al. J. Biosci. 35 (1) :21-25 (2010)
Background Reference 04
Aldahmesh, M.A., et al. Ophthalmic Genet. 30 (4) :185-189 (2009)
Other Product Names
Cystinosin, CTNS
Tested Applications
WB
Physical Properties
Liquid
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