ACO2 Antibody

Product Specifications

Background

ACO2 belongs to the aconitase/IPM isomerase family. It is an enzyme that catalyzes the interconversion of citrate to isocitrate via cis-aconitate in the second step of the TCA cycle. This protein is encoded in the nucleus and functions in the mitochondrion. It was found to be one of the mitochondrial matrix proteins that are preferentially degraded by the serine protease 15 (PRSS15), also known as Lon protease, after oxidative modification.

NCBI Gene ID

Swiss Prot

Q99798

Accession Number

Q99798

Host

Rabbit

Reactivity

Human, Rat

Immunogen

This ACO2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 438-467 amino acids from the Central region of human ACO2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Obesity, Signal Transduction

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Pig, Bovine

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

85 kDa

Fragment

Rabbit Ig

Symbol

ACO2

NCBI Official Name

Aconitate hydratase, mitochondrial

NCBI Organism

Homo sapiens

Background Reference 01

Juang, H.H., Mol. Genet. Metab. 81 (3) :244-252 (2004) .

Background Reference 02

Bota, D.A., et al., Nat. Cell Biol. 4 (9) :674-680 (2002) .

Background Reference 03

Gruer, M.J., et al., Trends Biochem. Sci. 22 (1) :3-6 (1997) .

Background Reference 04

Klausner, R.D., et al., Mol. Biol. Cell 4 (1) :1-5 (1993) .

Other Product Names

Aconitate hydratase, mitochondrial, Aconitase, Citrate hydro-lyase, ACO2

Tested Applications

WB, IHC-P

Protein ID

6686275

Physical Properties

Liquid

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