APC Antibody

Product Specifications

Background

This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.

NCBI Gene ID

324

Swiss Prot

P25054

Accession Number

P25054

Host

Rabbit

Reactivity

Mouse

Immunogen

This APC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1148-1176 amino acids from the Central region of human APC.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle, Neuroscience, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

312 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

APC

NCBI Official Name

Adenomatous polyposis coli protein

NCBI Organism

Homo sapiens

Background Reference 01

Chung, K.H., et al.Neurosurg Pediatr 6 (4) :372-376 (2010)

Background Reference 02

Rai, K., et al. Cell 142 (6) :930-942 (2010)

Background Reference 03

Poulogiannis, G., et al. Proc. Natl. Acad. Sci. U.S.A. 107 (34) :15145-15150 (2010)

Background Reference 04

Jaulin, F., et al. J. Cell Biol. 190 (3) :443-460 (2010)

Other Product Names

Adenomatous polyposis coli protein, Protein APC, Deleted in polyposis 25, APC, DP25

Tested Applications

Protein ID

97535708

Physical Properties

Liquid

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