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Mouse Shb Antibody

Product Specifications

Background

Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells (By similarity) .

NCBI Gene ID

230126

Swiss Prot

Q6PD21

Accession Number

Q6PD21

Host

Rabbit

Reactivity

Mouse

Immunogen

This Mouse Shb antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 68-95 amino acids from the C-terminal region of mouse Shb.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Human

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

55 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

Shb

NCBI Official Name

SH2 domain-containing adapter protein B

NCBI Organism

Mus musculus

Background Reference 01

Calounova, G., et al. PLoS ONE (6), E11155 (2010) :

Background Reference 02

Akerblom, B., et al. J. Endocrinol. 203 (2) :271-279 (2009)

Background Reference 03

Mokhtari, D., et al. Biochem. Biophys. Res. Commun. 387 (3) :553-557 (2009)

Background Reference 04

Funa, N.S., et al. Cancer Res. 69 (5) :2141-2148 (2009)

Other Product Names

SH2 domain-containing adapter protein B, Shb

Tested Applications

WB

Physical Properties

Liquid

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