RNF6 Antibody
Product Specifications
Background
The protein encoded by this gene contains a RING-H2 finger motif. Deletions and mutations in this gene were detected in esophageal squamous cell carcinoma (ESCC), suggesting that this protein may be a potential tumor suppressor. Studies of the mouse counterpart suggested a role of this protein in the transcription regulation that controls germinal differentiation. Multiple alternatively spliced transcript variants encoding the same protein are observed.
NCBI Gene ID
6049
Swiss Prot
Q9Y252
Accession Number
Q9Y252
Host
Rabbit
Reactivity
Human
Immunogen
This RNF6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 529-558 amino acids from the C-terminal region of human RNF6.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
78 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
RNF6
NCBI Official Name
E3 ubiquitin-protein ligase RNF6
NCBI Organism
Homo sapiens
Background Reference 01
Xu, K., et al. Cancer Cell 15 (4) :270-282 (2009)
Background Reference 02
Zhu, L., et al. Sci. China, C, Life Sci. 51 (4) :302-307 (2008)
Background Reference 03
Tursun, B., et al. Genes Dev. 19 (19) :2307-2319 (2005)
Background Reference 04
Lo, H.S., et al. Cancer Res. 62 (15) :4191-4193 (2002)
Other Product Names
E3 ubiquitin-protein ligase RNF6, 632-, RNF6, SPG2
Tested Applications
WB
Protein ID
13124536
Physical Properties
Liquid
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