EGF Antibody

Product Specifications

Background

This gene encodes a member of the epidermal growth factor superfamily. The encoded protein is synthesized as a large precursor molecule that is proteolytically cleaved to generate the 53-amino acid epidermal growth factor peptide. This protein acts a potent mitogenic factor that plays an important role in the growth, proliferation and differentiation of numerous cell types. This protein acts by binding the high affinity cell surface receptor, epidermal growth factor receptor. Defects in this gene are the cause of hypomagnesemia type 4. Dysregulation of this gene has been associated with the growth and progression of certain cancers. Alternate splicing results in multiple transcript variants.

NCBI Gene ID

1950

Swiss Prot

P01133

Accession Number

P01133

Host

Rabbit

Reactivity

Human

Immunogen

This EGF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 940-967 amino acids from the C-terminal region of human EGF.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

134 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

EGF

NCBI Official Name

Pro-epidermal growth factor

NCBI Organism

Homo sapiens

Background Reference 01

De Diesbach, M.T., et al. Exp. Cell Res. 316 (19) :3239-3253 (2010)

Background Reference 02

Xu, Z., et al. Biochem. Biophys. Res. Commun. 401 (3) :376-381 (2010)

Background Reference 03

Lupien, M., et al. Genes Dev. 24 (19) :2219-2227 (2010)

Background Reference 04

Hommel, U., et al. J. Mol. Biol. 227 (1) :271-282 (1992)

Other Product Names

Pro-epidermal growth factor, EGF, Epidermal growth factor, Urogastrone, EGF

Tested Applications

Protein ID

251757262

Physical Properties

Liquid

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