ACCN3 Antibody

Product Specifications

Background

This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, two hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene is an acid sensor and may play an important role in the detection of lasting pH changes. In addition, a heteromeric association between this member and ACCN1 has been observed as proton-gated channels sensitive to gadolinium. Alternative splicing of this gene generates three transcript variants encoding distinct isoforms.

NCBI Gene ID

9311

Swiss Prot

Q9UHC3

Accession Number

Q9UHC3

Host

Rabbit

Reactivity

Human

Immunogen

This ACCN3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 55-83 amino acids from the N-terminal region of human ACCN3.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

59 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

ASIC3

NCBI Official Name

Acid-sensing ion channel 3

NCBI Organism

Homo sapiens

Background Reference 01

Borzan, J., et al. Anesthesiology 113 (3) :647-654 (2010)

Background Reference 02

Wu, S., et al. Clin. Chim. Acta 411 (15-16), 1132-1136 (2010) :

Background Reference 03

Ko, Y.L., et al. J. Hypertens. 26 (11) :2154-2160 (2008)

Background Reference 04

Su, X., et al. J. Biol. Chem. 281 (48) :36960-36968 (2006)

Other Product Names

Acid-sensing ion channel 3, ASIC3, hASIC3, Amiloride-sensitive cation channel 3, Neuronal amiloride-sensitive cation channel 3, Testis sodium channel 1, hTNaC1, ASIC3, ACCN3, SLNAC1, TNAC1