MCCC2 Antibody

Product Specifications

Background

This gene encodes the small subunit of 3-methylcrotonyl-CoA carboxylase. This enzyme functions as a heterodimer and catalyzes the carboxylation of 3-methylcrotonyl-CoA to form 3-methylglutaconyl-CoA. Mutations in this gene are associated with 3-Methylcrotonylglycinuria, an autosomal recessive disorder of leucine catabolism.

NCBI Gene ID

64087

Swiss Prot

Q9HCC0

Accession Number

Q9HCC0

Host

Rabbit

Reactivity

Human

Immunogen

This MCCC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 468-496 amino acids from the C-terminal region of human MCCC2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Obesity, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

61 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

MCCC2

NCBI Official Name

Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial

NCBI Organism

Homo sapiens

Background Reference 01

Yoshida, T., et al. Int. J. Mol. Med. 25 (4) :649-656 (2010) Oguri, M., et al. Am. J. Hypertens. 23 (1) :70-77 (2010) Cho, Y.S., et al. Proteins 70 (1) :268-272 (2008) Uematsu, M., et al. J. Hum. Genet. 52 (12) :1040-1043 (2007) Stadler, S.C., et al. Biochem. Biophys. Res. Commun. 334 (3) :939-946 (2005)

Other Product Names

Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial, MCCase subunit beta, 3-methylcrotonyl-CoA carboxylase 2, 3-methylcrotonyl-CoA carboxylase non-biotin-containing subunit, 3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta, MCCC2, MCCB