API5 Antibody

Product Specifications

Background

Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs.

NCBI Gene ID

8539

Swiss Prot

Q9BZZ5

Accession Number

Q9BZZ5

Host

Rabbit

Reactivity

Human

Immunogen

This API5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 482-510 amino acids from the C-terminal region of human API5.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

59 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

API5

NCBI Official Name

Apoptosis inhibitor 5

NCBI Organism

Homo sapiens

Background Reference 01

Wang, Z., et al. Med. Sci. Monit. 16 (8), CR357-CR364 (2010) :

Background Reference 02

Ren, K., et al. Pathol. Oncol. Res. 16 (2) :229-237 (2010)

Background Reference 03

Need, A.C., et al. Hum. Mol. Genet. 18 (23) :4650-4661 (2009)

Background Reference 04

Rigou, P., et al. EMBO J. 28 (11) :1576-1588 (2009)

Other Product Names

Apoptosis inhibitor 5, API-5, Antiapoptosis clone 11 protein, AAC-11, Cell migration-inducing gene 8 protein, Fibroblast growth factor 2-interacting factor, FIF, Protein XAGL, API5