TRPC4AP Antibody

Product Specifications

Background

Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. The DCX (TRUSS) complex specifically mediates the polyubiquitination and subsequent degradation of MYC. Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the IKK signalosome. Involved in JNK activation via its interaction with TRAF2. Also involved in elevation of endoplasmic reticulum Ca (2+) storage reduction in response to CHRM1.

NCBI Gene ID

26133

Swiss Prot

Q8TEL6

Accession Number

Q8TEL6

Host

Rabbit

Reactivity

Human

Immunogen

This TRPC4AP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 49-75 amino acids from the N-terminal region of human TRPC4AP.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

91 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

TRPC4AP

NCBI Official Name

Short transient receptor potential channel 4-associated protein

NCBI Organism

Homo sapiens

Background Reference 01

Mace, K.E., et al. J. Cell. Physiol. 225 (2) :444-453 (2010)

Background Reference 02

Choi, S.H., et al. Genes Dev. 24 (12) :1236-1241 (2010)

Background Reference 03

Poduslo, S.E., et al. Neurosci. Lett. 450 (3) :344-346 (2009)

Background Reference 04

Poduslo, S.E., et al. Am. J. Med. Genet.Neuropsychiatr. Genet. 150B (1), 50-55 (2009) :

Other Product Names

Short transient receptor potential channel 4-associated protein, Trp4-associated protein, Trpc4-associated protein, Protein TAP1, TNF-receptor ubiquitous scaffolding/signaling protein, Protein TRUSS, TRPC4AP, C20orf188, TRRP4AP