AFF2 Antibody

Product Specifications

Background

This gene encodes a putative transcriptional activator that is a member of the AF4FMR2 gene family. This gene is associated with the folate-sensitive fragile X E locus on chromosome X. A repeat polymorphism in the fragile X E locus results in silencing of this gene causing Fragile X E syndrome. Fragile X E syndrome is a form of nonsyndromic X-linked mental retardation. Alternate splicing results in multiple transcript variants.

NCBI Gene ID

2334

Swiss Prot

P51816

Accession Number

P51816

Host

Rabbit

Reactivity

Human

Immunogen

This AFF2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 886-912 amino acids from the Central region of human AFF2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

145 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

AFF2

NCBI Official Name

AF4/FMR2 family member 2

NCBI Organism

Homo sapiens

Background Reference 01

Bensaid, M., et al. Nucleic Acids Res. 37 (4) :1269-1279 (2009)

Background Reference 02

Brylawski, B.P., et al. Exp. Mol. Pathol. 82 (2) :190-196 (2007)

Background Reference 03

Sharma, D., et al. Genet. Epidemiol. 20 (1) :129-144 (2001)

Background Reference 04

Hillman, M.A., et al. J. Hum. Genet. 46 (5) :251-259 (2001)

Other Product Names

AF4/FMR2 family member 2, Fragile X E mental retardation syndrome protein, Fragile X mental retardation 2 protein, FMR2P, Protein FMR-2, Protein Ox19, AFF2, FMR2, OX19