ALG11 Antibody

Product Specifications

Background

This gene encodes a GDP-Man:Man3GlcNAc2-PP-dolichol-alpha1,2-mannosyltransferase which is localized to the cytosolic side of the endoplasmic reticulum (ER) and catalyzes the transfer of the fourth and fifth mannose residue from GDP-mannose (GDP-Man) to Man3GlcNAc2-PP-dolichol and Man4GlcNAc2-PP-dolichol resulting in the production of Man5GlcNAc2-PP-dolichol. Mutations in this gene are associated with congenital disorder of glycosylation type Ip (CDGIP) . This gene overlaps but is distinct from the UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast) gene. A pseudogene of the GDP-Man:Man3GlcNAc2-PP-dolichol-alpha1,2-mannosyltransferase has been identified on chromosome 19.

NCBI Gene ID

440138

Swiss Prot

Q2TAA5

Accession Number

Q2TAA5

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This ALG11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 442-468 amino acids from the C-terminal region of human ALG11.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

56 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

ALG11

NCBI Official Name

GDP-Man:Man (3) GlcNAc (2) -PP-Dol alpha-1,2-mannosyltransferase

NCBI Organism

Homo sapiens

Background Reference 01

Rind, N., et al. Hum. Mol. Genet. 19 (8) :1413-1424 (2010)

Background Reference 02

Rohozinski, J., et al. Biol. Reprod. 74 (4) :644-651 (2006)

Other Product Names

GDP-Man:Man (3) GlcNAc (2) -PP-Dol alpha-1,2-mannosyltransferase, Asparagine-linked glycosylation protein 11 homolog, Glycolipid 2-alpha-mannosyltransferase, ALG11, GT8