SPO11 Antibody

Product Specifications

Background

Meiotic recombination and chromosome segregation require the formation of double-strand breaks (DSBs) in paired chromosome homologs. During meiosis in yeast, a meiotic recombination protein is covalently-linked to the 5' end of DSBs and is essential for the formation of DSBs. The protein encoded by this gene is similar in sequence and conserved features to the yeast meiotic recombination protein. The encoded protein belongs to the TOP6A protein family. Several transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been described.

NCBI Gene ID

23626

Swiss Prot

Q9Y5K1

Accession Number

Q9Y5K1

Host

Rabbit

Reactivity

Human

Immunogen

This SPO11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 299-326 amino acids from the C-terminal region of human SPO11.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

45 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

SPO11

NCBI Official Name

Meiotic recombination protein SPO11

NCBI Organism

Homo sapiens

Background Reference 01

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :

Background Reference 02

Aston, K.I., et al. Hum. Reprod. 25 (6) :1383-1397 (2010)

Background Reference 03

Mandon-Pepin, B., et al. Eur. J. Endocrinol. 158 (1) :107-115 (2008)

Background Reference 04

Christensen, G.L., et al. Fertil. Steril. 84 (3) :758-760 (2005)

Other Product Names

Meiotic recombination protein SPO11, Cancer/testis antigen 35, CT35, SPO11

Tested Applications

Protein ID

7674367

Physical Properties

Liquid

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