ALG2 Antibody

Product Specifications

Background

This gene encodes a member of the glycosyltransferase 1 family. The encoded protein acts as an alpha 1,3 mannosyltransferase, mannosylating Man (2) GlcNAc (2) -dolichol diphosphate and Man (1) GlcNAc (2) -dolichol diphosphate to form Man (3) GlcNAc (2) -dolichol diphosphate. Defects in this gene have been associated with congenital disorder of glycosylation type Ih (CDG-Ii) . Alternative splicing results in multiple transcript variants.

NCBI Gene ID

85365

Swiss Prot

Q9H553

Accession Number

Q9H553

Host

Rabbit

Reactivity

Human

Immunogen

This ALG2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 254-282 amino acids from the Central region of human ALG2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

47 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

ALG2

NCBI Official Name

Alpha-1,3/1,6-mannosyltransferase ALG2

NCBI Organism

Homo sapiens

Background Reference 01

Inuzuka, T., et al. BMC Struct. Biol. 10, 25 (2010) :

Background Reference 02

Okumura, M., et al. Biochem. Biophys. Res. Commun. 386 (1) :237-241 (2009)

Background Reference 03

Hoj, B.R., et al. Biochem. Biophys. Res. Commun. 378 (1) :145-148 (2009)

Background Reference 04

Mahul-Mellier, A.L., et al. J. Biol. Chem. 283 (50) :34954-34965 (2008)

Other Product Names

Alpha-1,3/1,6-mannosyltransferase ALG2, Asparagine-linked glycosylation protein 2 homolog, GDP-Man:Man (1) GlcNAc (2) -PP-Dol alpha-1,3-mannosyltransferase, GDP-Man:Man (1) GlcNAc (2) -PP-dolichol mannosyltransferase, GDP-Man:Man (2) GlcNAc (2) -PP-Dol alpha-1,6-mannosyltransferase, ALG2