CDC14A Antibody

Product Specifications

Background

The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. It is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, suggesting a role in cell cycle control. This protein has been shown to interact with, and dephosphorylate tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splicing of this gene results in several transcript variants encoding distinct isoforms. [provided by RefSeq].

NCBI Gene ID

8556

Swiss Prot

Q9UNH5

Accession Number

Q9UNH5

Host

Rabbit

Reactivity

Human

Immunogen

This CDC14A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 473-500 amino acids from the C-terminal region of human CDC14A.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

67 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

CDC14A

NCBI Official Name

Dual specificity protein phosphatase CDC14A

NCBI Organism

Homo sapiens

Background Reference 01

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :

Background Reference 02

Olson, J.E., et al. Breast Cancer Res. Treat. (2010) In press :

Background Reference 03

Mocciaro, A., et al. J. Cell Biol. 189 (4) :631-639 (2010)

Background Reference 04

Song, S.Y., et al. APMIS 118 (5) :389-393 (2010)

Other Product Names

Dual specificity protein phosphatase CDC14A, CDC14 cell division cycle 14 homolog A, CDC14A

Tested Applications

Protein ID

55976620

Physical Properties

Liquid

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