PDGFA Antibody

PDGFA is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer or as a heterodimer with the platelet-derived growth factor beta polypeptide, where the dimers are connected by disulfide bonds. Studies using knockout mice have shown cellular defects in oligodendrocytes, alveolar smooth muscle cells, and Leydig cells in the testis; knockout mice die either as embryos or shortly after birth.

This PDGFA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 60-89 amino acids from the N-terminal region of human PDGFA.

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Monje, P., et al., Mol. Cell. Biol. 23 (19) :7030-7043 (2003) . Gianni, D., et al., J. Biol. Chem. 278 (11) :9290-9297 (2003) . Muller, C., et al., J. Biol. Chem. 278 (20) :18330-18335 (2003) . Chui, C.M., et al., Cytokine 21 (2) :51-64 (2003) . Laprise, M.H., et al., Blood 100 (10) :3578-3587 (2002) .

Platelet-derived growth factor subunit A, PDGF subunit A, PDGF-1, Platelet-derived growth factor A chain, Platelet-derived growth factor alpha polypeptide, PDGFA, PDGF1