CDC42EP2 Antibody

Product Specifications

Background

CDC42, a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to, and negatively regulate the function of, CDC42. Coexpression of this protein with dominant negative mutant CDC42 protein in fibroblast was found to induce pseudopodia formation, which suggested a role of this protein in actin filament assembly and cell shape control.

NCBI Gene ID

10435

Swiss Prot

O14613

Accession Number

O14613

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This CDC42EP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 133-160 amino acids from the C-terminal region of human CDC42EP2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

22 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

CDC42EP2

NCBI Official Name

Cdc42 effector protein 2

NCBI Organism

Homo sapiens

Background Reference 01

Xue, Y., et al. Int. J. Cancer 118 (12) :2965-2972 (2006)

Background Reference 02

Joberty, G., et al. Nat. Cell Biol. 3 (10) :861-866 (2001)

Background Reference 03

Hirsch, D.S., et al. J. Biol. Chem. 276 (2) :875-883 (2001)

Background Reference 04

Joberty, G., et al. Mol. Cell. Biol. 19 (10) :6585-6597 (1999)

Other Product Names

Cdc42 effector protein 2, Binder of Rho GTPases 1, CDC42EP2, BORG1, CEP2

Tested Applications

Physical Properties

Liquid

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