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KRT3 Antibody

Product Specifications

Background

The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the corneal epithelium with family member KRT12 and mutations in these genes have been associated with Meesmann's Corneal Dystrophy. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.

NCBI Gene ID

3850

Swiss Prot

P12035

Accession Number

P12035

Host

Rabbit

Reactivity

Human

Immunogen

This KRT3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 414-441 amino acids from the Central region of human KRT3.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Immunology, Neuroscience, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

64 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

KRT3

NCBI Official Name

Keratin, type II cytoskeletal 3

NCBI Organism

Homo sapiens

Background Reference 01

Szaflik, J.P., et al. Mol. Vis. 14, 1713-1718 (2008) :

Background Reference 02

Schweizer, J., et al. J. Cell Biol. 174 (2) :169-174 (2006)

Background Reference 03

Chen, Y.T., et al. Cornea 24 (8) :928-932 (2005)

Background Reference 04

Rogers, M.A., et al. J. Invest. Dermatol. 124 (3) :536-544 (2005)

Other Product Names

Keratin, type II cytoskeletal 3, 65 kDa cytokeratin, Cytokeratin-3, CK-3, Keratin-3, K3, Type-II keratin Kb3, KRT3

Tested Applications

WB

Protein ID

313104225

Physical Properties

Liquid

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