EPOR Antibody
Product Specifications
Background
This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants.
NCBI Gene ID
2057
Swiss Prot
P19235
Accession Number
P19235
Host
Rabbit
Reactivity
Human
Immunogen
This EPOR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 329-357 amino acids from the Central region of human EPOR.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
55 kDa
Fragment
Rabbit Ig
Symbol
EPOR
NCBI Official Name
Erythropoietin receptor
NCBI Organism
Homo sapiens
Background Reference 01
Lim, A.C., et al. Biochemistry 49 (18) :3797-3804 (2010)
Background Reference 02
Perrotta, S., et al. PLoS ONE (8), E12015 (2010) :
Background Reference 03
Khankin, E.V., et al. PLoS ONE (2), E9246 (2010) :
Background Reference 04
Wincewicz, A., et al. Folia Histochem. Cytobiol. 47 (3) :425-430 (2009)
Other Product Names
Erythropoietin receptor, EPO-R, EPOR
Tested Applications
WB, IF, Flow
Protein ID
119524
Physical Properties
Liquid
Curated Selection
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