CDCA4 Antibody

Product Specifications

Background

This gene encodes a protein that belongs to the E2F family of transcription factors. This protein regulates E2F-dependent transcriptional activation and cell proliferation, mainly through the E2F/retinoblastoma protein pathway. It also functions in the regulaton of JUN oncogene expression. This protein shows distinctive nuclear-mitotic apparatus distribution, it is involved in spindle organization from prometaphase, and may also play a role as a midzone factor involved in chromosome segregation or cytokinesis. Two alternatively spliced transcript variants encoding the same protein have been noted for this gene. Two pseudogenes have also been identified on chromosome 1.

NCBI Gene ID

55038

Swiss Prot

Q9BXL8

Accession Number

Q9BXL8

Host

Rabbit

Reactivity

Human

Immunogen

This CDCA4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 163-190 amino acids from the C-terminal region of human CDCA4.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

26 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

CDCA4

NCBI Official Name

Cell division cycle-associated protein 4

NCBI Organism

Homo sapiens

Background Reference 01

Tategu, M., et al. Biochimie 90 (10) :1515-1522 (2008)

Background Reference 02

Wang, L., et al. Cell Motil. Cytoskeleton 65 (7) :581-593 (2008)

Background Reference 03

Hayashi, R., et al. J. Biol. Chem. 281 (47) :35633-35648 (2006)

Background Reference 04

Walker, M.G. Curr Cancer Drug Targets 1 (1) :73-83 (2001)

Other Product Names

Cell division cycle-associated protein 4, Hematopoietic progenitor protein, CDCA4, HEPP

Tested Applications

Protein ID

32699606

Physical Properties

Liquid

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