GUCA2B Antibody

Product Specifications

Background

Uroguanylin and guanylin (GUCA2A; MIM 139392), peptide homologs of the bacterial heat-stable enterotoxins (e.g., the E. coli ST toxin; STa), are endogenous activators of the guanylate cyclase-2C receptor (GUCY2C; MIM 601330), which synthesizes cyclic GMP (cGMP), a key component of several intracellular signal transduction pathways.

NCBI Gene ID

2981

Swiss Prot

Q16661

Accession Number

Q16661

Host

Rabbit

Reactivity

Human

Immunogen

This GUCA2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 69-97 amino acids from the C-terminal region of human GUCA2B.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

12 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

GUCA2B

NCBI Official Name

Guanylate cyclase activator 2B

NCBI Organism

Homo sapiens

Background Reference 01

Yoshikawa, Y., et al. Hypertens. Res. 30 (9) :789-796 (2007)

Background Reference 02

Guo, H.F., et al. Zhonghua Xin Xue Guan Bing Za Zhi 35 (3) :233-236 (2007)

Background Reference 03

Sindic, A., et al. Kidney Int. 67 (4) :1420-1427 (2005)

Background Reference 04

Maake, C., et al. Histochem. Cell Biol. 119 (1) :69-76 (2003)

Other Product Names

Guanylate cyclase activator 2B, Guanylate cyclase C-activating peptide 2, Guanylate cyclase C-activating peptide II, GCAP-II, Uroguanylin, UGN, GUCA2B