Mouse Mapk14 Antibody

Product Specifications

Background

Responds to activation by environmental stress, pro-inflammatory cytokines and lipopolysaccharide (LPS) by phosphorylating a number of transcription factors, such as ELK1 and ATF2 and several downstream kinases, such as MAPKAPK2 and MAPKAPK5. Plays a critical role in the production of some cytokines, for example IL-6. Required in mid-fetal development for the growth of embryo-derived blood vessels in the labyrinth layer of the placenta. Also plays an essential role in developmental and stress-induced erythropoiesis, through regulation of EPO gene expression.

NCBI Gene ID

26416

Swiss Prot

P47811

Accession Number

P47811

Host

Rabbit

Reactivity

Human

Immunogen

This Mouse Mapk14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 26-53 amino acids from the N-terminal region of mouse Mapk14.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle, Immunology, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

41 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

Mapk14

NCBI Official Name

Mitogen-activated protein kinase 14

NCBI Organism

Mus musculus

Background Reference 01

Pan, W.W., et al. J. Biol. Chem. 285 (45) :34348-34354 (2010)

Background Reference 02

Menon, M.B., et al. J. Biol. Chem. 285 (43) :33242-33251 (2010)

Background Reference 03

Chandrakesan, P., et al. J. Biol. Chem. 285 (43) :33485-33498 (2010)

Background Reference 04

Ferreiro, I., et al. J. Biol. Chem. 285 (41) :31819-31828 (2010)

Other Product Names

Mitogen-activated protein kinase 14, MAP kinase 14, MAPK 14, CRK1, Mitogen-activated protein kinase p38 alpha, MAP kinase p38 alpha, Mapk14, Crk1, Csbp1, Csbp2