TRPM4 Antibody

Product Specifications

Background

The protein encoded by this gene is a calcium-activated nonselective ion channel that mediates transport of monovalent cations across membranes, thereby depolarizing the membrane. The activity of the encoded protein increases with increasing intracellular calcium concentration, but this channel does not transport calcium. Two transcript variants encoding different isoforms have been found for this gene.

NCBI Gene ID

54795

Swiss Prot

Q8TD43

Accession Number

Q8TD43

Host

Rabbit

Reactivity

Human

Immunogen

This TRPM4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1121-1149 amino acids from the C-terminal region of human TRPM4.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Obesity, Neuroscience, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

134 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

TRPM4

NCBI Official Name

Transient receptor potential cation channel subfamily M member 4

NCBI Organism

Homo sapiens

Background Reference 01

Liu, H., et al. Circ Cardiovasc Genet 3 (4) :374-385 (2010)

Background Reference 02

Yoo, J.C., et al. Biochem. Biophys. Res. Commun. 391 (1) :806-811 (2010)

Background Reference 03

Kruse, M., et al. J. Clin. Invest. 119 (9) :2737-2744 (2009)

Background Reference 04

Marigo, V., et al. Mol. Cell. Endocrinol. 299 (2) :194-203 (2009)

Other Product Names

Transient receptor potential cation channel subfamily M member 4, hTRPM4, Calcium-activated non-selective cation channel 1, Long transient receptor potential channel 4, LTrpC-4, LTrpC4, Melastatin-4, TRPM4, LTRPC4