Mouse TLR6 Antibody
Product Specifications
Background
TLR6, a Type I membrane protein that belongs to the Toll-like rceptor family, participates in the innate immune response to Gram-positive bacteria and fungi. It acts via MyD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. The protein recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2. It binds to TLR2 via their respective extracellular domains, and to MyD88 via their respective TIR domains. TLR6 is detected in monocytes, CD11c+ immature dendritic cells, plasmacytoid pre-dendritic cells and dermal microvessel endothelial cells.
NCBI Gene ID
21899
Swiss Prot
Q9EPW9
Accession Number
Q9EPW9
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This Mouse TLR6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 722-753 amino acids from the C-terminal region of mouse TLR6.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=58-164
Calculated Molecular Weight
91 kDa
Fragment
Rabbit Ig
Symbol
Tlr6
NCBI Official Name
Toll-like receptor 6
NCBI Organism
Mus musculus
Background Reference 01
Ozinsky, A., et al., Proc. Natl. Acad. Sci. U.S.A. 97 (25) :13766-13771 (2000) .
Background Reference 02
Takeuchi, O., et al., Gene 231 (1-2), 59-65 (1999) .
Other Product Names
Toll-like receptor 6, CD286, Tlr6
Tested Applications
WB, IHC-P
Physical Properties
Liquid
Curated Selection
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