GPER Antibody

Product Specifications

Background

This gene is a member of the G-protein coupled receptor 1 family and encodes a multi-pass membrane protein that localizes to the endoplasmic reticulum. The protein binds estrogen, resulting in intracellular calcium mobilization and synthesis of phosphatidylinositol 3,4,5-trisphosphate in the nucleus. This protein therefore plays a role in the rapid nongenomic signaling events widely observed following stimulation of cells and tissues with estrogen. Alternate transcriptional splice variants which encode the same protein have been characterized. [provided by RefSeq].

NCBI Gene ID

2852

Swiss Prot

Q99527

Accession Number

Q99527

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This GPER antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 346-375 amino acids from the C-terminal region of human GPER.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Obesity, Neuroscience, Signal Transduction, Growth Factors

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

42 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

GPER1

NCBI Official Name

G-protein coupled estrogen receptor 1

NCBI Organism

Homo sapiens

Background Reference 01

Patel, V.H., et al. Int. J. Mol. Med. 26 (2) :193-199 (2010)

Background Reference 02

Ignatov, A., et al. Breast Cancer Res. Treat. 123 (1) :87-96 (2010)

Background Reference 03

Li, Y., et al. Mol. Endocrinol. 24 (5) :969-980 (2010)

Background Reference 04

Kang, L., et al. Mol. Endocrinol. 24 (4) :709-721 (2010)

Other Product Names

G-protein coupled estrogen receptor 1, Chemoattractant receptor-like 2, Flow-induced endothelial G-protein coupled receptor 1, FEG-1, G protein-coupled estrogen receptor 1, G-protein coupled receptor 30, GPCR-Br, IL8-related receptor DRY12, Lymphocyte-derived G-protein coupled receptor, LYGPR, Membrane estrogen receptor, mER, GPER1, CEPR, CMKRL2, DRY12, GPER, GPR30