PKD2 Antibody

Product Specifications

Background

This gene encodes a member of the polycystin protein family. The encoded protein contains multiple transmembrane domains, and cytoplasmic N- and C-termini. The protein may be an integral membrane protein involved in cell-cell/matrix interactions. The encoded protein may function in renal tubular development, morphology, and function, and may modulate intracellular calcium homoeostasis and other signal transduction pathways. This protein interacts with polycystin 1 to produce cation-permeable currents. Mutations in this gene have been associated with autosomal dominant polycystic kidney disease.

NCBI Gene ID

5311

Swiss Prot

Q13563

Accession Number

Q13563

Host

Rabbit

Reactivity

Mouse

Immunogen

This PKD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 874-903 amino acids from the C-terminal region of human PKD2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Obesity, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

110 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

PKD2

NCBI Official Name

Polycystin-2

NCBI Organism

Homo sapiens

Background Reference 01

Duning, K., et al. J. Biol. Chem. 285 (44) :33584-33588 (2010)

Background Reference 02

Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)

Background Reference 03

Stewart, A.P., et al. Biophys. J. 99 (3) :790-797 (2010)

Background Reference 04

Petri, E.T., et al. Proc. Natl. Acad. Sci. U.S.A. 107 (20) :9176-9181 (2010)

Other Product Names

Polycystin-2, Autosomal dominant polycystic kidney disease type II protein, Polycystic kidney disease 2 protein, Polycystwin, R48321, PKD2

Tested Applications

Protein ID

116242717

Physical Properties

Liquid

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