DNMT3A Antibody

Product Specifications

Background

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq].

NCBI Gene ID

1788

Swiss Prot

Q9Y6K1

Accession Number

Q9Y6K1

Host

Rabbit

Reactivity

Human

Immunogen

This DNMT3A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 457-486 amino acids from the Central region of human DNMT3A.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

102 kDa

Fragment

Rabbit Ig

Symbol

DNMT3A

NCBI Official Name

DNA (cytosine-5) -methyltransferase 3A

NCBI Organism

Homo sapiens

Background Reference 01

Holz-Schietinger, C., et al. J. Biol. Chem. 285 (38) :29091-29100 (2010) Kelemen, L.E., et al. Cancer Epidemiol. Biomarkers Prev. 19 (7) :1822-1830 (2010) Park, C.W., et al.Cardiovasc Transl Res 3 (3) :290-295 (2010) Haggarty, P., et al. PLoS ONE (6), E11329 (2010) Zhao, Z., et al. J. Biomed. Biotechnol. 2010, 737535 (2010) :