Mouse Aurka Antibody
Product Specifications
Background
Contributes to the regulation of cell cycle progression. Required for normal mitosis. Associates with the centrosome and the spindle microtubules during mitosis and functions in centrosome maturation, spindle assembly, maintenance of spindle bipolarity, centrosome separation and mitotic checkpoint control. Phosphorylates numerous target proteins, including ARHGEF2, BRCA1, KIF2A, NDEL1, PARD3, PLK1 and BORA. Regulates KIF2A tubulin depolymerase activity (By similarity) . Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization.
NCBI Gene ID
20878
Swiss Prot
P97477
Accession Number
P97477
Host
Rabbit
Reactivity
Mouse
Immunogen
This Mouse Aurka antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 93-120 amino acids from the N-terminal region of mouse Aurka.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=57-856
Calculated Molecular Weight
45 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
Aurka
NCBI Official Name
Aurora kinase A
NCBI Organism
Mus musculus
Background Reference 01
Kinzel, D., et al. Dev. Cell 19 (1) :66-77 (2010)
Background Reference 02
Van Horn, R.D., et al. J. Biol. Chem. 285 (28) :21849-21857 (2010)
Background Reference 03
Mori, D., et al. Nat. Cell Biol. 11 (9) :1057-1068 (2009)
Background Reference 04
Li, C.C., et al. Mol. Cancer Res. 7 (5) :678-688 (2009)
Other Product Names
Aurora kinase A, Aurora 2, Aurora family kinase 1, Aurora/IPL1-related kinase 1, ARK-1, Aurora-related kinase 1, Ipl1- and aurora-related kinase 1, Serine/threonine-protein kinase 6, Serine/threonine-protein kinase Ayk1, Serine/threonine-protein kinase aurora-A, Aurka
Tested Applications
WB
Physical Properties
Liquid
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