HTR1B Antibody

Product Specifications

Background

The neurotransmitter serotonin (5-hydroxytryptamine; 5-HT) exerts a wide variety of physiologic functions through a multiplicity of receptors and may be involved in human neuropsychiatric disorders such as anxiety, depression, or migraine. These receptors consist of several main groups subdivided into several distinct subtypes on the basis of their pharmacologic characteristics, coupling to intracellular second messengers, and distribution within the nervous system (Zifa and Fillion, 1992 [PubMed 1359584]) . The serotonergic receptors belong to the multigene family of receptors coupled to guanine nucleotide-binding proteins.

NCBI Gene ID

3351

Swiss Prot

P28222

Accession Number

P28222

Host

Rabbit

Reactivity

Human

Immunogen

This HTR1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 225-253 amino acids from the Central region of human HTR1B.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Obesity, Neuroscience, Growth Factors

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Pig, Rabbit

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

44 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

HTR1B

NCBI Official Name

5-hydroxytryptamine receptor 1B

NCBI Organism

Homo sapiens

Background Reference 01

Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010) Kiezebrink, K., et al. World J. Biol. Psychiatry 11 (6) :824-833 (2010) Mekli, K., et al. Eur Neuropsychopharmacol (2010) In pressPinheiro, A.P., et al. Am. J. Med. Genet.Neuropsychiatr. Genet. 153B (5), 1070-1080 (2010) Cross, D.S., et al. BMC Genet. 11, 51 (2010) :