IDE Antibody

Product Specifications

Background

IDE belongs to a protease family responsible for intercellular peptide signalling. Though its role in the cellular processing of insulin has not yet been defined, insulin-degrading enzyme is thought to be involved in the termination of the insulin response.

NCBI Gene ID

3416

Swiss Prot

P14735

Accession Number

P14735

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This IDE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 406-435 amino acids from the Central region of human IDE.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle, Obesity, Neuroscience, Signal Transduction

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Rat, Bovine

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

118 kDa

Fragment

Rabbit Ig

Symbol

IDE

NCBI Official Name

Insulin-degrading enzyme

NCBI Organism

Homo sapiens

Background Reference 01

Vepsalainen, S., J. Med. Genet. 44 (9), 606-608 (2007)

Background Reference 02

Kim, M., J. Biol. Chem. 282 (11), 7825-7832 (2007)

Background Reference 03

Radulescu, R.T., Int. J. Oncol. 30 (1), 73-80 (2007)

Background Reference 04

Li, Q., Cell 127 (2), 305-316 (2006)

Other Product Names

Insulin-degrading enzyme, Abeta-degrading protease, Insulin protease, Insulinase, Insulysin, IDE

Tested Applications

WB, IHC-P

Protein ID

215274252

Physical Properties

Liquid

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