RIPK3 Antibody

Product Specifications

Background

The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor.

NCBI Gene ID

11035

Swiss Prot

Q9Y572

Accession Number

Q9Y572

Host

Rabbit

Reactivity

Human

Immunogen

This RIPK3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 480-509 amino acids from the C-terminal region of human RIPK3.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle, Immunology, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

57 kDa

Fragment

Rabbit Ig

Symbol

RIPK3

NCBI Official Name

Receptor-interacting serine/threonine-protein kinase 3

NCBI Organism

Homo sapiens

Background Reference 01

Jugessur, A., et al. PLoS ONE (7), E11493 (2010) :

Background Reference 02

Vandenabeele, P., et al. Sci Signal (115), RE4 (2010) :

Background Reference 03

Cho, Y.S., et al. Cell 137 (6) :1112-1123 (2009)

Background Reference 04

He, S., et al. Cell 137 (6) :1100-1111 (2009)

Other Product Names

Receptor-interacting serine/threonine-protein kinase 3, RIP-like protein kinase 3, Receptor-interacting protein 3, RIP-3, RIPK3, RIP3

Tested Applications

WB, IHC-P

Protein ID

205371831

Physical Properties

Liquid

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