PYGM Antibody

Product Specifications

Background

PYGM catalyzes and regulates the breakdown of glycogen to glucose-1-phosphate. Defects in PYGM are the cause of glycogen storage disease type 5 (GSD5), also known as McArdle disease. GSD5 is a metabolic disorder resulting in myopathy characterized by exercise intolerance, cramps, muscle weakness and recurrent myoglobinuria.

NCBI Gene ID

5837

Swiss Prot

P11217

Accession Number

P11217

Host

Rabbit

Reactivity

Human

Immunogen

This PYGM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 698-727 amino acids from the C-terminal region of human PYGM.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Obesity, Signal Transduction

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Monkey

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

97 kDa

Fragment

Rabbit Ig

Symbol

PYGM

NCBI Official Name

Glycogen phosphorylase, muscle form

NCBI Organism

Homo sapiens

Background Reference 01

Tsoi, S.C., et al., J. Soc. Gynecol. Investig. 10 (8) :496-502 (2003) .

Background Reference 02

Bruno, C., et al., Neuromuscul. Disord. 12 (5) :498-500 (2002) .

Background Reference 03

Hadjigeorgiou, G.M., et al., Neuromuscul. Disord. 12 (9) :824-827 (2002) .

Background Reference 04

Deschauer, M., et al., Mol. Genet. Metab. 74 (4) :489-491 (2001) .

Other Product Names

Glycogen phosphorylase, muscle form, Myophosphorylase, PYGM

Tested Applications

WB, IHC-P

Protein ID

3041717

Physical Properties

Liquid

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