Mouse Pak4 Antibody
Product Specifications
Background
Pak4 activates the JNK pathway. Plays a role in the reorganization of the actin cytoskeleton and in the formation of filopodia. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates ARHGEF2 (By similarity) .
NCBI Gene ID
70584
Swiss Prot
Q8BTW9
Accession Number
Q8BTW9
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This Mouse Pak4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 187-216 amino acids from the Central region of mouse Pak4.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
65 kDa
Fragment
Rabbit Ig
Symbol
Pak4
NCBI Official Name
Serine/threonine-protein kinase PAK 4
NCBI Organism
Mus musculus
Background Reference 01
Liu, Y., et al. Oncogene 29 (44) :5883-5894 (2010)
Background Reference 02
Tian, Y., et al. Mech. Dev. 126 (8-9), 710-720 (2009) :
Background Reference 03
Ha, U.H., et al. J. Biol. Chem. 283 (45) :30624-30631 (2008)
Background Reference 04
Liu, Y., et al. Mol. Cancer Res. 6 (7) :1215-1224 (2008)
Other Product Names
Serine/threonine-protein kinase PAK 4, p21-activated kinase 4, PAK-4, Pak4, Kiaa1142
Tested Applications
WB, Flow
Physical Properties
Liquid
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