CCDC50 Antibody

Product Specifications

Background

This gene encodes a soluble, cytoplasmic, tyrosine-phosphorylated protein with multiple ubiquitin-interacting domains. Mutations in this gene cause nonsyndromic, postlingual, progressive sensorineural DFNA44 hearing loss. In mouse, the protein is expressed in the inner ear during development and postnatal maturation and associates with microtubule-based structures. This protein may also function as a negative regulator of NF-kB signaling and as an effector of epidermal growth factor (EGF) -mediated cell signaling. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq].

NCBI Gene ID

152137

Swiss Prot

Q8IVM0

Accession Number

Q8IVM0

Host

Rabbit

Reactivity

Human

Immunogen

This CCDC50 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 86-114 amino acids from the Central region of human CCDC50.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

36 kDa

Fragment

Rabbit Ig

Symbol

CCDC50

NCBI Official Name

Coiled-coil domain-containing protein 50

NCBI Organism

Homo sapiens

Background Reference 01

Farfsing, A., et al. Leukemia 23 (11) :2018-2026 (2009)

Background Reference 02

Kameda, H., et al. Biochem. Biophys. Res. Commun. 378 (4) :744-749 (2009)

Background Reference 03

Bohgaki, M., et al. Biochim. Biophys. Acta 1783 (5) :826-837 (2008)

Background Reference 04

Modamio-Hoybjor, S., et al. Am. J. Hum. Genet. 80 (6) :1076-1089 (2007)

Other Product Names

Coiled-coil domain-containing protein 50, Protein Ymer, CCDC50, C3orf6

Tested Applications

WB, IHC-P

Protein ID

73619722

Physical Properties

Liquid

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