RNF19A Antibody

Product Specifications

Background

The protein encoded this gene contains two RING-finger motifs and an IBR (in between RING fingers) motif. This protein is an E3 ubiquintin ligase that is localized in Lewy bodies (LBs), a characteristic neuronal inclusion in Parkinson's disease (PD) brains. This protein interacts with UBE2L3/UBCH7 and UBE2E2/UBCH8, but not other ubiquitin-conjugating enzymes. This protein is found to bind and ubiquitylate synphilin 1 (SNCAIP), which is a interacting protein of alpha synuclein in neurons, and a major component of LB. Alternatively spliced transcript variants encoding the same protein have been reported.

NCBI Gene ID

25897

Swiss Prot

Q9NV58

Accession Number

Q9NV58

Host

Rabbit

Reactivity

Human

Immunogen

This RNF19A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 384-413 amino acids from the Central region of human RNF19A.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle, Neuroscience

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse, Pig

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

91 kDa

Fragment

Rabbit Ig

Symbol

RNF19A

NCBI Official Name

E3 ubiquitin-protein ligase RNF19A

NCBI Organism

Homo sapiens

Background Reference 01

Huh, J.W., et al. Gene 424 (1-2), 63-70 (2008) :

Background Reference 02

Matsuoka, S., et al. Science 316 (5828) :1160-1166 (2007)

Background Reference 03

Ishigaki, S., et al. Neurobiol. Dis. 25 (2) :331-341 (2007)

Background Reference 04

Huang, Y., et al. J. Biol. Chem. 281 (17) :11610-11617 (2006)

Other Product Names

E3 ubiquitin-protein ligase RNF19A, 632-, Double ring-finger protein, Dorfin, RING finger protein 19A, p38, RNF19A, RNF19

Tested Applications

WB, IHC-P

Protein ID

116242764

Physical Properties

Liquid

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