JAM2 Antibody

Product Specifications

Background

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is localized in the tight junctions between high endothelial cells. It acts as an adhesive ligand for interacting with a variety of immune cell types and may play a role in lymphocyte homing to secondary lymphoid organs. [provided by RefSeq].

NCBI Gene ID

58494

Swiss Prot

P57087

Accession Number

P57087

Host

Rabbit

Reactivity

Human

Immunogen

This JAM2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 63-91 amino acids from the N-terminal region of human JAM2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

33 kDa

Fragment

Rabbit Ig

Symbol

JAM2

NCBI Official Name

Junctional adhesion molecule B

NCBI Organism

Homo sapiens

Background Reference 01

Need, A.C., et al. Hum. Mol. Genet. 18 (23) :4650-4661 (2009)

Background Reference 02

Ueki, T., et al. Microvasc. Res. 75 (2) :269-278 (2008)

Background Reference 03

Weber, C., et al. Nat. Rev. Immunol. 7 (6) :467-477 (2007)

Background Reference 04

Liu, T., et al. J. Proteome Res. 4 (6) :2070-2080 (2005)

Other Product Names

Junctional adhesion molecule B, JAM-B, Junctional adhesion molecule 2, JAM-2, Vascular endothelial junction-associated molecule, VE-JAM, CD322, JAM2, C21orf43, VEJAM