CIR Antibody
Product Specifications
Background
CIR may modulate splice site selection during alternative splicing of pre-mRNAs. It regulates transcription and acts as corepressor for RBPSUH. It recruits RBPSUH to the Sin3-histone deacetylase complex (HDAC), and is required for RBPSUH-mediated repression of transcription.
NCBI Gene ID
9541
Swiss Prot
Q86X95
Accession Number
Q86X95
Host
Rabbit
Reactivity
Human
Immunogen
This CIR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 396-424 amino acids from the C-terminal region of human CIR.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
52 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
CIR1
NCBI Official Name
Corepressor interacting with RBPJ 1
NCBI Organism
Homo sapiens
Background Reference 01
Olsen, J.V., Cell 127 (3), 635-648 (2006)
Background Reference 02
Maita, H., Exp. Cell Res. 303 (2), 375-387 (2005)
Background Reference 03
Zhou, S., Mol. Cell. Biol. 21 (18), 6222-6232 (2001)
Other Product Names
Corepressor interacting with RBPJ 1, CBF1-interacting corepressor, Recepin, CIR1, CIR
Tested Applications
WB
Protein ID
74727790
Physical Properties
Liquid
Curated Selection
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