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Mouse Map2k5 Antibody

Product Specifications

Background

Map2k5 acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appear to play a critical role in protecting cells from stress-induced apopotosis, neuronal survival and cardiac development and angiogenesis.

NCBI Gene ID

23938

Swiss Prot

Q9WVS7

Accession Number

Q9WVS7

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This Mouse Map2k5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 385-412 amino acids from the C-terminal region of mouse Map2k5.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

50 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

Map2k5

NCBI Official Name

Dual specificity mitogen-activated protein kinase kinase 5

NCBI Organism

Mus musculus

Background Reference 01

Spiering, D., et al. J. Biol. Chem. 284 (37) :24972-24980 (2009)

Background Reference 02

Carter, E.J., et al. J. Cell. Sci. 122 (PT 17), 3104-3112 (2009) :

Background Reference 03

Sohn, S.J., et al. EMBO J. 27 (13) :1896-1906 (2008)

Background Reference 04

Shishido, T., et al. Circ. Res. 102 (11) :1416-1425 (2008)

Other Product Names

Dual specificity mitogen-activated protein kinase kinase 5, MAP kinase kinase 5, MAPKK 5, MAPK/ERK kinase 5, MEK 5, Map2k5, Mek5, Mkk5, Prkmk5

Tested Applications

WB

Physical Properties

Liquid

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