IBSP Antibody

Product Specifications

Background

The protein encoded by this gene is a major structural protein of the bone matrix. It constitutes approximately 12% of the noncollagenous proteins in human bone and is synthesized by skeletal-associated cell types, including hypertrophic chondrocytes, osteoblasts, osteocytes, and osteoclasts. The only extraskeletal site of its synthesis is the trophoblast. This protein binds to calcium and hydroxyapatite via its acidic amino acid clusters, and mediates cell attachment through an RGD sequence that recognizes the vitronectin receptor.

NCBI Gene ID

3381

Swiss Prot

P21815

Accession Number

P21815

Host

Rabbit

Reactivity

Human

Immunogen

This IBSP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 70-99 amino acids from the N-terminal region of human IBSP.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

35 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

IBSP

NCBI Official Name

Bone sialoprotein 2

NCBI Organism

Homo sapiens

Background Reference 01

Giroux, S., et al. Bone 47 (5) :975-981 (2010)

Background Reference 02

Koller, D.L., et al. J. Clin. Endocrinol. Metab. 95 (4) :1802-1809 (2010)

Background Reference 03

Yerges, L.M., et al. J. Bone Miner. Res. 24 (12) :2039-2049 (2009)

Background Reference 04

Gordon, J.A., et al. J. Cell. Biochem. 107 (6) :1118-1128 (2009)

Other Product Names

Bone sialoprotein 2, Bone sialoprotein II, BSP II, Cell-binding sialoprotein, Integrin-binding sialoprotein, IBSP, BNSP

Tested Applications

Protein ID

317373545

Physical Properties

Liquid

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