MIST Antibody

Product Specifications

Background

MIST is a member of the SLP76 family of adaptors (see LCP2, MIM 601603; BLNK, MIM 604515) . MIST plays a role in the regulation of immunoreceptor signaling, including PLC-gamma (PLCG1; MIM 172420) -mediated B cell antigen receptor (BCR) signaling and FC-epsilon R1 (see FCER1A, MIM 147140) -mediated mast cell degranulation (Cao et al., 1999 [PubMed 10562326]; Goitsuka et al., 2000, 2001 [PubMed 10744659] [PubMed 11463797]) .

NCBI Gene ID

116449

Swiss Prot

Q7Z7G1

Accession Number

Q7Z7G1

Host

Rabbit

Reactivity

Human

Immunogen

This MIST antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 281-308 amino acids from the Central region of human MIST.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Immunology, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

50 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

CLNK

NCBI Official Name

Cytokine-dependent hematopoietic cell linker

NCBI Organism

Homo sapiens

Background Reference 01

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :

Background Reference 02

Cronin, S., et al. Eur. J. Hum. Genet. 17 (2) :213-218 (2009)

Background Reference 03

Goitsuka, R., et al. J. Biol. Chem. 276 (38) :36043-36050 (2001)

Background Reference 04

Goitsuka, R., et al. Int. Immunol. 12 (4) :573-580 (2000)

Other Product Names

Cytokine-dependent hematopoietic cell linker, Mast cell immunoreceptor signal transducer, CLNK, MIST

Tested Applications

Protein ID

166217263

Physical Properties

Liquid

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