AP2A1 Antibody

Product Specifications

Background

This gene encodes the alpha 1 adaptin subunit of the adaptor protein 2 (AP-2) complex found in clathrin coated vesicles. The AP-2 complex is a heterotetramer consisting of two large adaptins (alpha or beta), a medium adaptin (mu), and a small adaptin (sigma) . The complex is part of the protein coat on the cytoplasmic face of coated vesicles which links clathrin to receptors in vesicles. Alternative splicing of this gene results in two transcript variants encoding two different isoforms. A third transcript variant has been described, but its full length nature has not been determined.

NCBI Gene ID

160

Swiss Prot

O95782

Accession Number

O95782

Host

Rabbit

Reactivity

Human

Immunogen

This AP2A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 706-735 amino acids from the C-terminal region of human AP2A1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

108 kDa

Fragment

Rabbit Ig

Symbol

AP2A1

NCBI Official Name

AP-2 complex subunit alpha-1

NCBI Organism

Homo sapiens

Background Reference 01

Mitchell, R.S., et al. J. Virol. 82 (16) :7758-7767 (2008)

Background Reference 02

Kitagawa, Y., et al. Virology 373 (1) :171-180 (2008)

Background Reference 03

Stove, V., et al. J. Virol. 79 (17) :11422-11433 (2005)

Background Reference 04

Lu, W., et al. Neuron 47 (3) :407-421 (2005)

Other Product Names

AP-2 complex subunit alpha-1, 100 kDa coated vesicle protein A, Adaptor protein complex AP-2 subunit alpha-1, Adaptor-related protein complex 2 subunit alpha-1, Alpha-adaptin A, Alpha1-adaptin, Clathrin assembly protein complex 2 alpha-A large chain, Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit, AP2A1, ADTAA, CLAPA1