PTF1A Antibody

Product Specifications

Background

This gene encodes a protein that is a component of the pancreas transcription factor 1 complex (PTF1) and is known to have a role in mammalian pancreatic development. The protein plays a role in determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. The protein is thought to be involved in the maintenance of exocrine pancreas-specific gene expression including elastase 1 and amylase. Mutations in this gene cause cerebellar agenesis and loss of expression is seen in ductal type pancreas cancers.

NCBI Gene ID

256297

Swiss Prot

Q7RTS3

Accession Number

Q7RTS3

Host

Rabbit

Reactivity

Human

Immunogen

This PTF1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 287-316 amino acids from the C-terminal region of human PTF1A.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

35 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

PTF1A

NCBI Official Name

Pancreas transcription factor 1 subunit alpha

NCBI Organism

Homo sapiens

Background Reference 01

Meredith, D.M., et al. J. Neurosci. 29 (36) :11139-11148 (2009)

Background Reference 02

Rodolosse, A., et al. Biochem. J. 418 (2) :463-473 (2009)

Background Reference 03

Tutak, E., et al. Genet. Couns. 20 (2) :147-152 (2009)

Background Reference 04

Yamada, M., et al. J. Neurosci. 27 (41) :10924-10934 (2007)

Other Product Names

Pancreas transcription factor 1 subunit alpha, Class A basic helix-loop-helix protein 29, bHLHa29, Pancreas-specific transcription factor 1a, bHLH transcription factor p48, p48 DNA-binding subunit of transcription factor PTF1, PTF1-p48, PTF1A, BHLHA29, PTF1P48