RARA Antibody

Product Specifications

Background

This gene represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. This gene has been implicated in regulation of development, differentiation, apoptosis, granulopoeisis, and transcription of clock genes. Translocations between this locus and several other loci have been associated with acute promyelocytic leukemia. Alternatively spliced transcript variants have been found for this locus.

NCBI Gene ID

5914

Swiss Prot

P10276

Accession Number

P10276

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This RARA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 322-349 amino acids from the C-terminal region of human RARA.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

51 kDa

Fragment

Rabbit Ig

Symbol

RARA

NCBI Official Name

Retinoic acid receptor alpha

NCBI Organism

Homo sapiens

Background Reference 01

Park, U.H., et al. J. Biol. Chem. 285 (44) :34269-34278 (2010)

Background Reference 02

Asleson, A.D., et al. Cancer Genet. Cytogenet. 202 (1) :33-37 (2010)

Background Reference 03

Catalano, A., et al. Blood 110 (12) :4073-4076 (2007)

Background Reference 04

Wells, R.A., et al. Nat. Genet. 17 (1) :109-113 (1997)

Other Product Names

Retinoic acid receptor alpha, RAR-alpha, Nuclear receptor subfamily 1 group B member 1, RARA, NR1B1

Tested Applications

WB, IHC-P, IF, Flow

Protein ID

133483

Physical Properties

Liquid

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