LY6E Antibody

Product Specifications

Background

Sca1, also known as Ly6A/E, is a member of the Ly6 multigene family of type V glycophosphatidylinositol anchored cell surface proteins. It is expressed on multipotent hematopoietic stem cells in bone marrow of mice with both the Ly6.1 and Ly6.2 allotypes. In the periphery, Sca1 exhibits a pattern of expression which is based on differences between the two allotypes. Ly6.1 strains (e.g., A, BALB/c, CBA, C3H/He, DBA/1, NZB) have few Sca1+ resting peripheral lymphocytes, whereas Ly6.2 strains (e.g., AKR, C57BL, C57BR, C57L, DBA/2, PL, SJL, SWR, 129) have relatively high numbers of Sca1+ lymphocytes. The expression of Sca1 is dramatically upregulated in all strains upon cellular activation.

NCBI Gene ID

4061

Swiss Prot

Q16553

Accession Number

Q16553

Host

Rabbit

Reactivity

Human

Immunogen

This LY6E antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 41-70 amino acids from the Central region of human LY6E.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle, Immunology

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

14 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

LY6E

NCBI Official Name

Lymphocyte antigen 6E

NCBI Organism

Homo sapiens

Background Reference 01

Davila, S., et al. Genes Immun. 11 (3) :232-238 (2010)

Background Reference 02

Wang, J.L., et al. Mov. Disord. 24 (13) :2007-2011 (2009)

Background Reference 03

Socal, M.P., et al. Parkinsonism Relat. Disord. 15 (5) :374-378 (2009)

Background Reference 04

Tang, J., et al. Lupus 17 (9) :805-813 (2008)

Other Product Names

Lymphocyte antigen 6E, Ly-6E, Retinoic acid-induced gene E protein, RIG-E, Stem cell antigen 2, SCA-2, Thymic shared antigen 1, TSA-1, LY6E, RIGE, SCA2, TSA1