PPP4C Antibody

Product Specifications

Background

Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, tumor necrosis factor (TNF) -alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity) .

NCBI Gene ID

5531

Swiss Prot

P60510

Accession Number

P60510

Host

Rabbit

Reactivity

Human

Immunogen

This PPP4C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 160-189 amino acids from the Central region of human PPP4C.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Zebrafish, Bovine, Mouse, Rabbit, Rat, Xenopus

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

35 kDa

Fragment

Rabbit Ig

Symbol

PPP4C

NCBI Official Name

Serine/threonine-protein phosphatase 4 catalytic subunit

NCBI Organism

Homo sapiens

Background Reference 01

Lee, D.H., et al. Nat. Struct. Mol. Biol. 17 (3) :365-372 (2010)

Background Reference 02

Mourtada-Maarabouni, M., et al. Leuk. Res. 33 (11) :1539-1551 (2009)

Background Reference 03

Kumar, R.A., et al. PLoS ONE (2), E4582 (2009) :

Background Reference 04

Chen, G.I., et al. J. Biol. Chem. 283 (43) :29273-29284 (2008)

Other Product Names

Serine/threonine-protein phosphatase 4 catalytic subunit, PP4C, Pp4, Protein phosphatase X, PP-X, PPP4C, PPP4, PPX

Tested Applications

WB, IHC-P

Protein ID

44888846

Physical Properties

Liquid

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