SILV Antibody

Product Specifications

Background

SILV plays a central role in the biogenesis of melanosomes. Involved in the maturation of melanosomes from stage I to II. The transition from stage I melanosomes to stage II melanosomes involves an elongation of the vesicle, and the appearance within of distinct fibrillar structures. Release of the soluble form, ME20-S, could protect tumor cells from antibody mediated immunity.

NCBI Gene ID

6490

Swiss Prot

P40967

Accession Number

P40967

Host

Rabbit

Reactivity

Human

Immunogen

This SILV antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 412-440 amino acids from the Central region of human SILV.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Obesity, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

70 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

PMEL

NCBI Official Name

Melanocyte protein PMEL

NCBI Organism

Homo sapiens

Background Reference 01

Leonhardt, R.M., et al. J. Biol. Chem. 285 (21) :16166-16183 (2010)

Background Reference 02

Hoashi, T., et al. FASEB J. 24 (3) :916-930 (2010)

Background Reference 03

Watt, B., et al. J. Biol. Chem. 284 (51) :35543-35555 (2009)

Background Reference 04

McGlinchey, R.P., et al. Proc. Natl. Acad. Sci. U.S.A. 106 (33) :13731-13736 (2009)

Other Product Names

Melanocyte protein PMEL, ME20-M, ME20M, Melanocyte protein Pmel 17, Melanocytes lineage-specific antigen GP100, Melanoma-associated ME20 antigen, P1, P100, Premelanosome protein, Silver locus protein homolog, M-alpha, 95 kDa melanocyte-specific secreted glycoprotein, P26, Secreted melanoma-associated ME20 antigen, ME20-S, ME20S, M-beta, PMEL, D12S53E, PMEL17, SILV