CD27 Antibody

Product Specifications

Background

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor.

NCBI Gene ID

939

Swiss Prot

P26842

Accession Number

P26842

Host

Rabbit

Reactivity

Human

Immunogen

This CD27 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 196-225 amino acids from the C-terminal region of human CD27.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Immunology, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

29 kDa

Fragment

Rabbit Ig

Symbol

CD27

NCBI Official Name

CD27 antigen

NCBI Organism

Homo sapiens

Background Reference 01

Jiang, J., et al. J. Clin. Immunol. 30 (4) :566-573 (2010)

Background Reference 02

Arimoto-Miyamoto, K., et al. Immunology 130 (1) :137-149 (2010)

Background Reference 03

Mizuochi, T., et al. J. Interferon Cytokine Res. 30 (4) :243-252 (2010)

Background Reference 04

Davila, S., et al. Genes Immun. 11 (3) :232-238 (2010)

Other Product Names

CD27 antigen, CD27L receptor, T-cell activation antigen CD27, T14, Tumor necrosis factor receptor superfamily member 7, CD27, CD27, TNFRSF7

Tested Applications

WB, Flow

Protein ID

269849546

Physical Properties

Liquid

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